21c Museum Hotel Louisville

Luxury hotel with spa, near Ohio River Valley

Choose dates to view prices

Where to?

Dates

October 2025

November 2025

Room (Asleep in the Cyclone) | Premium bedding, down comforters, minibar, in-room safe

Unwind in the heart of Louisville at 21c Museum Hotel Louisville, where art and luxury meet. Treat yourself to a rejuvenating massage at the onsite spa, then enjoy breakfast or dinner at Proof on Main. With a 24-hour gym, dry cleaning services, and helpful staff by your side.

Exceptional

Popular amenities

Spa
Electric vehicle charging point
Bar
Connecting rooms available

Main amenities (12)

Daily housekeeping
Restaurant and bar/lounge
Full-service spa
Breakfast available
24-hour fitness center
Valet parking
Room service
Massage/treatment rooms
24-hour business center
Business center
Meeting rooms
Limo/town car service

Feel at home (6)

Free cribs/infant beds
Connecting/adjoining rooms available
Private bathroom
Premium TV channels
Daily housekeeping
Laundry facilities

$165 nightly

Oct 30 - Oct 31

Total with taxes and fees

Why we love this property

City center views

This boutique luxury hotel boasts breathtaking city panoramas, putting guests in the heart of urban vibrancy. Elegant design meets metropolitan charm.

Dining that delights

This hotel tantalizes taste buds with a restaurant, bar, and full breakfast offerings. Culinary adventures await morning through evening.

Luxury sleep retreat

Bathrobes, premium bedding, and hypo-allergenic comfort create a sumptuous sanctuary. The turndown service adds a final touch to this lavish sleep experience.

Room options

Check availability for these dates

Tonight

Oct 21 - Oct 22

Tomorrow

Oct 22 - Oct 23

All rooms

1 bed

2 beds

Showing 12 of 12 rooms

Deluxe Double Room, 2 Double Beds

Exceptional

Highlights

Soundproofed

Air conditioning

Connecting rooms available

Free cribs/infant beds

HDTV

Hypo-allergenic bedding

Premium bedding

Down duvet

335 sq ft
Sleeps 4
2 Double Beds

Luxury Double Room, 2 Double Beds

Wonderful

Highlights

Soundproofed

Air conditioning

Connecting rooms available

Free cribs/infant beds

HDTV

Hypo-allergenic bedding

Premium bedding

Down duvet

435 sq ft
Sleeps 4
2 Double Beds

Deluxe Room, 1 King Bed

Exceptional

Highlights

Soundproofed

Air conditioning

Connecting rooms available

Free cribs/infant beds

HDTV

Hypo-allergenic bedding

Premium bedding

Down duvet

350 sq ft
Sleeps 3
1 King Bed

Luxury Room, 1 King Bed

Wonderful

Highlights

Soundproofed

Air conditioning

Connecting rooms available

Free cribs/infant beds

HDTV

Hypo-allergenic bedding

Premium bedding

Down duvet

455 sq ft
Sleeps 3
1 King Bed

Suite, Corner

Highlights

Soundproofed

Air conditioning

Connecting rooms available

Free cribs/infant beds

HDTV

Hypo-allergenic bedding

Premium bedding

Down duvet

660 sq ft
Sleeps 3
1 King Bed

Room (Asleep in the Cyclone)

Highlights

Soundproofed

Air conditioning

Connecting rooms available

Free cribs/infant beds

HDTV

Hypo-allergenic bedding

Premium bedding

Down duvet

500 sq ft
Sleeps 3
1 King Bed

Suite (Atrium)

Highlights

Soundproofed

Air conditioning

Connecting rooms available

Free cribs/infant beds

HDTV

Hypo-allergenic bedding

Premium bedding

Down duvet

580 sq ft
Sleeps 3
1 King Bed

Room, Balcony

Exceptional

Highlights

Furnished balcony or patio

Soundproofed

Air conditioning

Connecting rooms available

Free cribs/infant beds

HDTV

Hypo-allergenic bedding

Premium bedding

315 sq ft
Sleeps 3
1 King Bed

Designer toiletries, hair dryer, bathrobes, towels

Deluxe Double Room, Accessible

Wonderful

Highlights

Soundproofed

Air conditioning

Connecting rooms available

Free cribs/infant beds

HDTV

Hypo-allergenic bedding

Premium bedding

Down duvet

455 sq ft
Sleeps 4
2 Double Beds

Premium bedding, down comforters, minibar, in-room safe

Deluxe Room, 1 King Bed, Accessible

Highlights

Soundproofed

Air conditioning

Connecting rooms available

Free cribs/infant beds

HDTV

Hypo-allergenic bedding

Premium bedding

Down duvet

434 sq ft
Sleeps 3
1 King Bed

Deluxe Room, 1 King Bed, Accessible

Highlights

Soundproofed

Air conditioning

Connecting rooms available

Free cribs/infant beds

HDTV

Hypo-allergenic bedding

Premium bedding

Down duvet

435 sq ft
Sleeps 3
1 King Bed

Apartment, 1 Double Bed (Rooftop)

Highlights

Furnished balcony or patio

Soundproofed

Air conditioning

Connecting rooms available

Free cribs/infant beds

HDTV

Hypo-allergenic bedding

Premium bedding

Sleeps 4
1 Double Bed

Similar properties

Sauna, body treatments, aromatherapy, hot stone massages

Pool
Spa
Pet friendly
Parking available

$199 nightly

Nov 3 - Nov 4

Total with taxes and fees

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About the neighborhood

700 W Main Street, Louisville, KY, 40202

What's nearby

Muhammad Ali Center - 3 min walk - 0.3 km
Louisville Slugger Museum - 3 min walk - 0.3 km
Fourth Street Live! - 8 min walk - 0.7 km
Kentucky International Convention Center - 8 min walk - 0.7 km
KFC Yum Center - 8 min walk - 0.7 km

Getting around

Louisville Intl. Airport (SDF) - 10 min drive
Louisville, KY (LOU-Bowman Field) - 11 min drive

Restaurants

‪Heine Brothers' Coffee - ‬3 min walk
‪Mussel & Burger Bar - ‬1 min walk
‪Sunergos Coffee and Espresso Bar - ‬6 min walk
‪Vincenzo's Italian Restaurant - ‬5 min walk
‪Pokehana - ‬5 min walk

About this property

21c Museum Hotel Louisville

You'll be in a fantastic location at 21c Museum Hotel Louisville, just a 5-minute walk from Ohio River Valley and Louisville Slugger Museum. Guests can indulge in massages at the spa, and Proof on Main serves breakfast, lunch, and dinner. This luxurious hotel also features a bar/lounge, a 24-hour fitness center, and a fitness center. Fellow travelers love the helpful staff and restaurant.

At a glance

Hotel size

- 91 rooms
- Arranged over 4 floors

Arriving/Leaving

- Check-in start time: 4 PM; Check-in end time: midnight
- Contactless check-in available
- Minimum check-in age: 21
- Check-out time is 11 AM
- Contactless check-out available

Special check-in instructions

- Front desk staff will greet guests on arrival at the property

Required at check-in

- Credit card required for incidental charges
- Government-issued photo ID may be required
- Minimum check-in age is 21

Pets

- Pets allowed (up to 50 lbs per pet)*
- Service animals welcome
- Food and water bowls available

Internet

- Free WiFi and wired internet access in public areas
- Free WiFi and wired internet access in rooms

Parking

- Onsite valet parking (USD 32 per night; includes in/out privileges)
- Wheelchair-accessible parking on site
- Electric vehicle charging point on site

Other information

- Smoke-free property

Property amenities

Food and drink

Full breakfast each morning (surcharge)
Restaurant
Bar/lounge
Coffee/tea in a common area
Room service (limited hours)

What to do

Yoga classes
Golfing nearby
Hiking/biking trails nearby

Working away

24-hour business center
Meeting rooms
Computer station
Conference space (5000 square feet)

Services

24-hour front desk
Concierge services
Tour/ticket assistance
Limo or town car service
Dry cleaning/laundry services
Free newspapers in lobby
Luggage storage
Multilingual staff
Porter/bellhop

Facilities

1 building/tower
Built in 2006
ATM/banking
Safe-deposit box at front desk
24-hour fitness center
Full-service spa
Massage/treatment rooms
At least 80% lighting from LEDs
No plastic soda bottles
No plastic coffee stirrers
No plastic drinking straws
No plastic water bottles
Reusable cups only
Reusable tableware only
Banquet hall

Accessibility

Wheelchair accessible
Braille/raised signage
Elevator
Wheelchair-accessible path of travel
Wheelchair-accessible parking
Assistive listening devices available
Wheelchair-accessible registration desk

Room amenities

Be entertained

50-inch LCD TV
Premium cable channels

Home comfort

Air conditioning (climate-controlled)
Minibar
Espresso maker
Bathrobes
Iron/ironing board

Sleep well

Hypo-allergenic bedding
Down comforter
Blackout drapes/curtains
Soundproofed rooms
Turndown service
Premium bedding
Free crib/infant bed
Rollaway/extra bed (surcharge)

What to enjoy

In-room massage

Freshen up

Private bathroom
Designer toiletries
Hair dryer
Towels
Toothbrush and toothpaste (on request)
Toilet paper

Stay connected

Desk
Free WiFi and wired internet
Free local calls

Food and drink

Free bottled water

Daily housekeeping
In-room safe (laptop compatible)
Connecting/adjoining rooms available
Eco-friendly toiletries
Eco-friendly cleaning products provided
LED light bulbs
Water-efficient showers only

Special features

Spa

Guests can pamper themselves with a trip to the onsite spa, which has 2 treatment rooms. Services include massages.

Dining

Proof on Main - This fine-dining restaurant serves breakfast, brunch, lunch, and dinner. Guests can enjoy drinks at the bar.

Awards and affiliations

Eco-Certified Property

This property participates in Green Key Global, a program that measures the property's impact on one or more of the following: environment, community, cultural-heritage, the local economy.

Fees & policies

Mandatory fees

You'll be asked to pay the following charges by the property at check-in or check-out. Fees may include applicable taxes:

Service fee: USD 5.00 per accommodation, per stay

Optional extras

Full breakfast is offered for an extra charge of approximately USD 5 to 25 per person

Children & extra beds

Rollaway beds are available for USD 30.0 per night

Pets

Service animals exempt from fees
Pets are allowed for an extra charge of USD 40.00 per accommodation, per stay

Parking

Valet parking costs USD 32 per night with in/out privileges

Pool, spa, & gym (if applicable)

Reservations are required for massage services and can be made by contacting the property before arrival at the number on the booking confirmation

Policies

The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.

Guests can rest easy knowing there's a carbon monoxide detector, a fire extinguisher, a smoke detector, a security system, a first aid kit, and window guards on site.

This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).

The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation.

This property accepts credit cards. Cash is not accepted.

Credit cards accepted: Visa, Mastercard, American Express, Discover

This property affirms that it follows the cleaning and disinfection practices of ALLSAFE (Accor Hotels).

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Frequently asked questions

Does 21c Museum Hotel Louisville offer free cancellation for a full refund?

Yes, 21c Museum Hotel Louisville does have fully refundable room rates available to book on our site. If you’ve booked a fully refundable room rate, this can be cancelled up to a few days before check-in depending on the property's cancellation policy. Just make sure to check this property's cancellation policy for the exact terms and conditions.

Are pets allowed at 21c Museum Hotel Louisville?

Yes, pets are welcome, with a maximum weight of 50 lbs per pet. There's a charge of USD 40.00 per accommodation, per stay. Service animals are exempt from fees. Food and water bowls are available.

Is parking offered on site at 21c Museum Hotel Louisville?

Yes. Valet parking costs USD 32 per night. Electric vehicle charging is available.

What are the check-in and check-out times at 21c Museum Hotel Louisville?

Check-in start time: 4 PM; Check-in end time: midnight. Check-out time is 11 AM. Contactless check-in and check-out are available.

Is there an onsite casino at 21c Museum Hotel Louisville?

No, this hotel doesn't have a casino, but Horseshoe Southern Indiana Casino (22-min drive) is nearby.

What is there to do at 21c Museum Hotel Louisville and nearby?

Have fun with nearby activities such as hiking and practice your swing at the nearby golf course. Additional recreation onsite includes yoga. Indulge in a treatment at the spa and enjoy other amenities such as a 24-hour fitness center and spa services.

Are there restaurants at or near 21c Museum Hotel Louisville?

Yes, there's an onsite restaurant, Proof on Main.

What's the area around 21c Museum Hotel Louisville like?

21c Museum Hotel Louisville is in Downtown Louisville, a short 10-minute drive from Louisville Intl. Airport (SDF) and 3 minutes' walk from Louisville Slugger Museum. Travelers say that the hotel is in a great location.