Hotels in Santa Isabel

Free cancellation options if plans change

Unlock travel rewards with One Key

Save more with Member Prices

Check prices for these dates

This weekend
Next weekend

Where to stay in Santa Isabel?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Check out reviews of Santa Isabel hotels guests love

Frequently asked questions

How much does a hotel room cost in Santa Isabel?
You can discover great hotels in Santa Isabel from $145 with properties to suit all budgets and needs. To find an affordable hotel in Santa Isabel that meets all of your requirements, just apply filters on Hotels.com, and sort hotels by "Price: low to high". If you're a member, don't forget to sign in to your account to unlock more savings.
How can I find deals and earn rewards at Santa Isabel hotels?
Members can save up to 20% on select hotels in Santa Isabel. Plus, Silver, Gold and Platinum members earn extra rewards on VIP Access bookings, making each stay even more rewarding.

Can I book Santa Isabel hotels with free cancellation?
It's easy to book a refundable Santa Isabel hotel on Hotels.com. Simply filter hotels by "Property cancellation options" and select "Fully refundable property". Many hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
Are all taxes and fees included in the Santa Isabel hotel prices shown on Hotels.com?
Hotels.com provides upfront pricing so you can relax knowing you won't be met with surprise additional fees or taxes when you're ready to confirm your booking. From the time you start your search on Hotels.com, the price you see is what you pay. This makes it much easier to compare properties and secure our best deal for your next getaway.
Can I book a refundable accommodation in Santa Isabel?
If you need the flexibility to change your plans to Santa Isabel, most hotels provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Santa Isabel be like during my vacation?
With an average temperature of 78°F during the coldest months, Santa Isabel is a great place to visit any time of year.
Why should I book my Santa Isabel accommodation with Hotels.com?
There are lots of reasons to book your Santa Isabel trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Find out more about Santa Isabel

Find out more about Santa Isabel

Discover the Enchantment of Santa Isabel: Nature’s Hidden Gem Awaits

Discover the hidden gem of Santa Isabel in Colón, Panama, where lush nature meets tranquil beaches. This off-the-beaten-path destination is perfect for eco-adventurers and those seeking solitude. Explore the nearby natural parks, teeming with diverse wildlife and stunning landscapes, or relax on pristine shores kissed by the Caribbean breeze. Enjoy authentic Panamanian cuisine in charming local eateries and immerse yourself in the warm hospitality of its residents. Whether you’re hiking through vibrant rainforests or soaking in the serene coastal vibes, Santa Isabel promises a unique and unforgettable escape for every traveler.

Discover great hotels in Santa Isabel

Santa Isabel, Colón, Panama offers a range of accommodations from comfortable rooms in stylish hotels to superior options for a luxurious stay. Whether you’re looking for a relaxing resort experience or charming boutique hotels, you’ll find inviting settings and great deals to enhance your vacation. These are some of the hotels preferred by our travelers in Santa Isabel:

  1. Cabañas Isla Nubesidub San BlasOpens in a new window: This charming 2.0-star lodge is perfect for leisure travelers seeking a beach vacation experience. With direct access to the beach, guests can indulge in sun-soaked days and refreshing ocean breezes. The property boasts a relaxed atmosphere that enhances the overall vacation vibe. Travelers appreciate the serene setting and the unique opportunity to unwind by the shore, making it an ideal choice for those looking to escape the hustle and bustle.
  2. Cabins on paradise San Blas islandOpens in a new window: Offering a delightful stay for leisure travelers, this 2.0-star hotel features a variety of dining options, including complimentary daily breakfast and a restaurant that serves local cuisine. The inviting ambiance and attention to culinary details create a memorable experience for guests. With its focus on comfort and quality, this hotel has garnered positive sentiments for its welcoming atmosphere and gourmet dining, making it a great choice for those eager to explore local flavors.
  3. Cabañas Nalunega San BlasOpens in a new window: This inviting 2.0-star lodge caters to leisure travelers with its delightful dining options, including lunch and dinner at the on-site restaurant. Guests can also enjoy various sports and recreation activities, such as boat tours, enhancing their experience. The lodge's appealing features and recreational offerings have led to positive feedback, reflecting a commitment to creating enjoyable and active vacations for those looking to immerse themselves in the local culture and natural beauty.

Top locations to stay in Santa Isabel

Some of the best areas to stay in Santa Isabel, Colón, Panama, are Palenque, Miramar, and Mandinga. Palenque offers vibrant local culture, while Miramar boasts stunning coastal views. Mandinga is known for its relaxed atmosphere and proximity to nature. For first-time visitors, Miramar is the ideal choice for its scenic beauty and accessibility.

  1. PalenqueOpens in a new window: Palenque is a vibrant spot known for its stunning coastal views and cultural experiences. Staying here gives you easy access to beautiful beaches and local markets where you can shop for handmade crafts and fresh produce. The area is also rich in history, with opportunities to explore traditional Panamanian villages nearby, making it a great choice for travelers who want a mix of relaxation and cultural immersion.
  2. MiramarOpens in a new window: Miramar boasts a picturesque waterfront and is a fantastic place for those looking to unwind by the sea. This area features a variety of outdoor activities, including water sports and scenic walking paths along the coast. You’ll find charming cafes and local shops, perfect for grabbing a bite or picking up unique souvenirs. The laid-back atmosphere makes it a great retreat for families and solo travelers alike.
  3. MandingaOpens in a new window: Mandinga offers a more secluded experience, ideal for travelers seeking tranquility and natural beauty. With its lush surroundings and serene beaches, it's perfect for those wanting to escape the hustle and bustle. This area is known for its stunning sunsets, and you can enjoy leisurely strolls along the shore or engage in local fishing activities. Mandinga is a hidden gem for anyone looking to connect with nature and unwind.

Things to do in Santa Isabel

Santa Isabel enchants visitors with its stunning natural beauty, featuring pristine beaches, lush forests, and majestic mountains. Travelers can indulge in hiking, swimming, or simply relaxing in serene parks and beside tranquil lakes. It's an ideal spot for nature lovers seeking rejuvenation and outdoor fun.

  • Porvenir MuseumOpens in a new window – Dive into the unique history of the region at Porvenir MuseumOpens in a new window. Here, you'll discover fascinating exhibits that showcase the local heritage and culture. This museum is not just about artifacts; it provides a window into the life and traditions of the people who have shaped this area over the years. Take your time exploring the displays and appreciate the connection between the past and the present.
  • Museum – Another gem worth visiting is the Museum, where you can continue your journey through the natural parks of Panama. This venue offers intriguing insights into the local environment and its diverse ecosystems. Enjoy the educational displays that highlight the importance of preserving nature while providing a rich understanding of the area's flora and fauna.

5 tips for savvy savings when booking a hotel in Santa Isabel

  1. Book for the cheapest times: The most budget-friendly time to visit Santa Isabel is during January, March, and May, when hotel prices may drop to lower levels. For those looking to explore the city's key landmarks, cultural sites, and natural parks, a stay of at least 1 to 2 days is recommended. This duration offers great value for money, allowing visitors to experience the rich history and stunning natural attractions without breaking the bank.
  2. Look for last-minute deals on Hotels.com: To discover last-minute deals to Santa Isabel, visit the DealsOpens in a new window or Last-Minute DealsOpens in a new window section on Hotels.com, where you may find discounted hotel rates as your travel date approaches. To stay informed about potential savings, consider enabling email alerts or push notifications for flash sales and special promotions. Additionally, the Smart ShoppingOpens in a new window tool available via the app allows you to compare hotel prices and amenities, helping you identify the best options. By using these resources, you're more likely to find great availability and make informed booking decisions for your last-minute getaway.
  3. Be flexible with dates: Prices can fluctuate based on factors like the hotel's location, star rating, and the time of year, so being flexible with your travel dates could help you save on your stay at the Santa Isabel hotel. If you’re interested in unique accommodations, boutique hotels often provide a more personalized experience and may offer better value. When you book through Hotels.com, we'll inform you whether the price for your chosen dates is above or below the average. If the price is on the higher end, we’ll suggest alternative dates that could help you find a better deal.
  4. Consider your location: Choosing to stay near major attractions or downtown areas can be convenient, but it often involves higher prices. For more budget-friendly options, you might look for hotels in neighborhoods that are usually located a bit farther from the center, allowing you to strike a balance between cost and accessibility to the sites you want to see. Additionally, independent hotels situated further out can offer a more genuine experience that is often more likely to be affordable.
  5. Become a Member: Join our membership program for free and unlock incredible savings on your next stay in Santa Isabel! With access to over 100,000 hotels worldwide, you can take advantage of exclusive member prices. As you progress through the membership tiers, you'll receive exciting perks such as complimentary room upgrades (when available) and discounts on food and beverages at select VIP Access properties. Don't miss out on these fantastic benefits—sign up today and start planning your getaway!