Hotels in Seneca

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Check prices for these dates

Tonight
8 Sept - 9 Sept
Tomorrow
9 Sept - 10 Sept
This weekend
11 Sept - 13 Sept
Next weekend
18 Sept - 20 Sept

Where to stay in Seneca?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Seneca on Hotels.com. These Seneca hotels consistently deliver on quality, location and traveller experience. Last updated on .

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
HK$877
HK$964 total
includes taxes & fees
27 Sept - 28 Sept
Tru by Hilton Seneca Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
HK$930
HK$1,023 total
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn & Suites Seneca-Clemson Area

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
HK$593
HK$699 total
includes taxes & fees
24 Sept - 25 Sept
Quality Inn Seneca US-123

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
HK$941
HK$1,035 total
includes taxes & fees
27 Sept - 28 Sept
Fairfield Inn & Suites Seneca Clemson Univ Area

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
HK$760
HK$836 total
includes taxes & fees
14 Sept - 15 Sept
Best Western Seneca-Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
HK$641
HK$815 total
includes taxes & fees
13 Sept - 14 Sept
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
HK$666
HK$733 total
includes taxes & fees
14 Sept - 15 Sept
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
HK$729
HK$1,147 total
includes taxes & fees
7 Oct - 8 Oct
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
Clemson
HK$829
HK$920 total
includes taxes & fees
15 Sept - 16 Sept
Hampton Inn Clemson-University Area

Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
Clemson
HK$876
HK$973 total
includes taxes & fees
9 Sept - 10 Sept
Clemson University's James F. Martin Inn

The Abernathy of Clemson

The Abernathy of Clemson
Clemson
HK$1,263
HK$1,402 total
includes taxes & fees
9 Sept - 10 Sept
The Abernathy of Clemson

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
HK$1,874
HK$2,080 total
includes taxes & fees
9 Sept - 10 Sept
The Shepherd Hotel Downtown Clemson

Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
Clemson
HK$826
HK$917 total
includes taxes & fees
4 Oct - 5 Oct
Comfort Inn & Suites Clemson - University Area

Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
Clemson
HK$1,011
HK$1,123 total
includes taxes & fees
9 Sept - 10 Sept
Holiday Inn Express & Suites Clemson by IHG

The Inn at Patrick Square

The Inn at Patrick Square
Clemson
HK$1,168
HK$1,297 total
includes taxes & fees
9 Sept - 10 Sept
The Inn at Patrick Square

Inn @ Clemson

Inn @ Clemson
Clemson
HK$590
HK$655 total
includes taxes & fees
9 Sept - 10 Sept
Inn @ Clemson

Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
Walhalla
HK$600
HK$669 total
includes taxes & fees
7 Oct - 8 Oct
Rodeway Inn & Suites Walhalla

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
Clemson
HK$793
HK$880 total
includes taxes & fees
14 Sept - 15 Sept
Best Western Plus Clemson Hotel & Conference Center

Courtyard Marriott Clemson

Courtyard Marriott Clemson
Clemson
HK$1,090
HK$1,210 total
includes taxes & fees
13 Sept - 14 Sept
Courtyard Marriott Clemson

Residence Inn by Marriott Anderson Clemson

Residence Inn by Marriott Anderson Clemson
Anderson
HK$1,121
HK$1,244 total
includes taxes & fees
27 Sept - 28 Sept
Residence Inn by Marriott Anderson Clemson
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Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
HK$705
per night
HK$827 total
includes taxes & fees
Quality Inn Seneca US-123

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
HK$641
per night
HK$815 total
includes taxes & fees
Lakeside Lodge Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
We have 3 left at
HK$1,090
per night
HK$1,199 total
includes taxes & fees
Tru by Hilton Seneca Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
We have 4 left at
HK$1,090
per night
HK$1,199 total
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
We have 5 left at
HK$1,090
per night
HK$1,199 total
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
HK$933
per night
HK$1,026 total
includes taxes & fees
Best Western Seneca-Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
HK$698
per night
HK$767 total
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
We have 2 left at
HK$855
per night
HK$1,285 total
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
HK$641
per night
HK$815 total
includes taxes & fees
Lakeside Lodge Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
We have 8 left at
HK$705
per night
HK$827 total
includes taxes & fees
Quality Inn Seneca US-123

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
We have 2 left at
HK$1,090
per night
HK$1,199 total
includes taxes & fees
Tru by Hilton Seneca Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
We have 4 left at
HK$1,090
per night
HK$1,199 total
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
HK$933
per night
HK$1,026 total
includes taxes & fees
Best Western Seneca-Clemson

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
We have 5 left at
HK$1,090
per night
HK$1,199 total
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
HK$698
per night
HK$767 total
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
We have 2 left at
HK$855
per night
HK$1,285 total
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
We have 1 left at
HK$3,097
per night
HK$7,059 total
includes taxes & fees
Quality Inn Seneca US-123

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
We have 1 left at
HK$3,998
per night
HK$8,796 total
includes taxes & fees
Best Western Seneca-Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
HK$3,136
per night
HK$6,899 total
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
We have 1 left at
HK$6,969
per night
HK$15,333 total
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Lake Keowee Gem! Close to Clemson & Hiking Trails

Lake Keowee Gem! Close to Clemson & Hiking Trails
Seneca
We have 1 left at
HK$6,170
per night
HK$15,631 total
includes taxes & fees
Lake Keowee Gem! Close to Clemson & Hiking Trails

Check out pet-friendly hotels in Seneca

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
HK$593
HK$699 total
includes taxes & fees
24 Sept - 25 Sept
Quality Inn Seneca US-123

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
HK$641
HK$815 total
includes taxes & fees
13 Sept - 14 Sept
Lakeside Lodge Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
HK$877
HK$964 total
includes taxes & fees
27 Sept - 28 Sept
Tru by Hilton Seneca Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
HK$666
HK$733 total
includes taxes & fees
14 Sept - 15 Sept
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
HK$729
HK$1,147 total
includes taxes & fees
7 Oct - 8 Oct
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
View all properties

You can also stay at hotels with a pool in Seneca

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
HK$641
HK$815 total
includes taxes & fees
13 Sept - 14 Sept
Lakeside Lodge Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
HK$593
HK$699 total
includes taxes & fees
24 Sept - 25 Sept
Quality Inn Seneca US-123

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
HK$930
HK$1,023 total
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn & Suites Seneca-Clemson Area

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
HK$760
HK$836 total
includes taxes & fees
14 Sept - 15 Sept
Best Western Seneca-Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
HK$666
HK$733 total
includes taxes & fees
14 Sept - 15 Sept
Days Inn by Wyndham Seneca / Clemson Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
HK$941
HK$1,035 total
includes taxes & fees
27 Sept - 28 Sept
Fairfield Inn & Suites Seneca Clemson Univ Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Our prices for hotels in Seneca are cheapest in December
Price trends for hotels in Seneca
Pricing is based on two traveller single night rates
View properties in September
Typical weather for Seneca
September
High 28°C / low 18°C. Sunny most days.
View properties in September
28°
18°
23°
12°
17°
12°
10°
13°
17°
22°
10°
26°
15°
31°
19°
32°
21°
31°
20°
Monthly weather averages (˚C)

Top neighbourhoods in Seneca

Downtown

City centre Seneca charms visitors with well-preserved historical buildings that tell the storey of its railway heritage. The tree-lined Ram Cat Alley showcases local history through colourful murals, while the old courthouse square hosts seasonal farmers markets and community events. You can explore the Bertha Lee Strickland Cultural Museum or browse antique shops filled with Southern treasures. Family-owned cafes serve up delicious Southern comfort food like fried green tomatoes and barbecue. Accommodation range from historic bed & breakfasts in Victorian homes to budget-friendly motels. The entire city centre is walkable with wide pavements, making it easy to discover this authentic slice of small-town America at your own pace.

Serenity Bay

Lake Keowee beckons from this peaceful coastal retreat nestled in Saxony Forest. Serenity Bay lives up to its name with tree-lined streets perfect for contemplative walks. Nearby Keowee Key Golf Course offers tee times for enthusiasts, while South Beach provides sandy relaxation without the crowds. The natural setting creates an ideal escape for bird watchers and nature photographers. Holiday rentals with weathered wood siding and muted earth tones blend seamlessly into the forest canopy. Getting around requires your own wheels since public transit is limited. The area trades bustling nightlife for cricket choruses and ocean breezes filtering through pine trees—exactly what makes this hidden gem worth finding.

Pine Ridge Point

Lake Keowee sparkles as the crown jewel of Pine Ridge Point, a peaceful residential haven in Seneca. Waterfront holiday homes nestle among tall pines, offering private docks and stunning views. Visitors spend days swimming in crystal-clear waters, boating across the lake, or simply unwinding on expansive decks beneath Carolina blue skies. This area is all about authentic lakeside living without commercial distractions. Most travellers cook in well-equipped rental kitchens or drive 15 minutes to Seneca for restaurants. Personal vehicles are essential for getting around, though scenic paths along the shoreline make for perfect evening strolls.

Indian Oaks

Indian Oaks gives you all the peaceful vibes of suburban life with none of the tourist chaos. This leafy area in Seneca lets you live like a local under a canopy of mature oak trees. The curved streets and manicured lawns create a park-like setting that's perfect for morning walks. Lake Keowee is just a short drive away when you need a water fix. You'll need wheels to get around since public transit is limited and restaurants aren't within walking distance. Most visitors stay in holiday rental homes with private yards and driveways. The area gets incredibly quiet after dark—ideal for travellers who want to experience authentic suburban living while having Seneca's attractions nearby.

Top landmarks in Seneca

A waterfall surrounded by autumn foliage.

High Falls County Park

High Falls County Park is worth a visit, located 7.8 mi (12.5 km) from central Seneca.
See properties
A grassy field with yellow flowers and trees in the foreground, with mountains in the background.

Blue Ridge Field

Blue Ridge Field is worth a visit, located 0.8 mi (1.2 km) from central Seneca.
See properties

Oconee County Library Seneca Branch

Oconee County Library Seneca Branch is worth a pic or two when discovering Downtown.
See properties

South Cove Park

South Cove Park is worth a visit, located 2 mi (3.3 km) from central Seneca.
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Friendship Recreation Area

Friendship Recreation Area is worth a visit, located 6.5 mi (10.5 km) from central Seneca.
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Seneca City Hall

Seneca City Hall is worth a pic or two when discovering Downtown.
See properties

World of Energy

If museums are on your list of things to see in Seneca, then you might want to head to World of Energy. If you want to experience more of the culture Seneca has to offer, head to Lake Keowee, High Falls County Park, and Keowee Key Golf Course.
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The Gauntlet

If you want to see a show while you're in town, try and grab some tickets at The Gauntlet in Downtown. If you enjoy the show and want to see another, Oconee Community Theatre isn't far.
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Learn more about Seneca

Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic city centre offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.

See all hotels in Seneca
A calm lake with mountains in the background.

Check out reviews of Seneca hotels guests love

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

10/10 Excellent
"Very clean...everyone there was polite and knowledgeable. Breakfast was very good also"
Joann 2-night trip
Posted 10 hours ago
Tru by Hilton Seneca Clemson
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"A unique experience, cabin provided everything needed except a mirror!! Close enough to town to get to stores and restaraunts easily but loved being far enough in the woods to enjoy the nature."
Phiilip M 1-night trip
Posted 19 hours ago
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

8/10 Good
"Decent if you’re just looking for a place to sleep. Breakfast wasn’t bad, just limited options. Room was fairly clean (didn’t look like it had been mopped) . But sheets/blankets/towels were super clean!"
Hunter 2-night trip
Posted 2 days ago
Days Inn by Wyndham Seneca / Clemson Area
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

10/10 Excellent
"The rooms were very clean and comfortable. Breakfast was outstanding good selection. I love the tranquility of this hotel."
Angela 2-night trip
Posted 2 days ago
Fairfield Inn & Suites Seneca Clemson Univ Area
Best Western Seneca-Clemson

Best Western Seneca-Clemson

8/10 Good
"The rooms were clean and the staff were very friendly."
Christine 3-night trip
Posted 3 days ago
Best Western Seneca-Clemson
Quality Inn Seneca US-123

Quality Inn Seneca US-123

8/10 Good
"Every thing was good"
Robert 4-night trip
Posted 4 days ago
Quality Inn Seneca US-123

Frequently asked questions

How much does a hotel room cost in Seneca?
You can find top hotels in Seneca from HK$655 with options to suit your budget and needs. If you're after an affordable hotel in Seneca that meets all of your requirements, set your filters and then sort the results by "Price: low to high".
How can I find deals and earn rewards at Seneca hotels?
Discover great deals on Seneca hotel stays with Hotels.com. You can also look at hotel prices mid-week or during the low season to find off-peak deals. And make sure to check out our last-minute deals on Seneca hotels.
Can I book Seneca hotels with free cancellation?
It's easy to book a refundable Seneca hotel on Hotels.com. Simply filter hotels by "Property cancellation options" and select "Fully refundable property". Most hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
What are some of the best Seneca hotels with free parking?
If you're exploring by car, finding a great Seneca hotel with free parking is a win. Our travellers' favourites include:
Can I book a refundable accommodation option in Seneca?
If you want the flexibility to change your plans to Seneca, most hotels offer refundable* rates that you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Seneca if I want a holiday rental instead of a hotel?
If you want a good alternative to a hotel, browse our selection of 219 holiday homes. In addition, there are 22 apartments and 13 condos.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August, with an average temperature of 25°C. January and February are the chilliest months, when the average temperature is 8°C. The rainiest months are December and January.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.

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