The rooms are very nice, the beds relaxing (though a little hard for my preference), and the showers extremely spacious with deliciously warm water. This last part was most important to me when my husband and I returned from our Ancascocha Trail trek to Machu Picchu. Though the front desk employees struggle a bit with English, they were more than helpful and tried their best to understand our needs and requests. The location is also decent, though there are not too many places to eat nearby (unless you are craving local pollo with a variety of fried starches). It takes about 15 minutes to walk to downtown Cusco. You do have to travel through some very pungent (and sometimes dirty-looking) marketplaces on your way to downtown. We were fine with this, but some days the smell could be a little overwhelming. If you are struggling with altitude sickness, this can definitely exacerbate the problem. The breakfast selection was also decent--buffet-style with eggs to order. If you are looking for something between insanely-priced downtown Cusco hotels and cheap and smelly hostels, Hotel Las Quenas might be a good choice for you.
By the way, in the description of this hotel a winery is mentioned. However, there is no winery on site (from what I could see) and the front desk had no clue what I was talking about when I asked.