I recommend Jumbo Hotel. The WiFi was adequate, the breakfast was good, and the staff were very friendly, even with an occasional language barrier (most staff I encountered spoke English well). By taxi, the hotel is approximately 10-15 minutes from the airport, and the MallDova shopping center is approximately 35 minutes' walk from the hotel. The other landmarks in the city center are a 10 minute bus ride away, which costs 10 cents (USD). A small convenience store is located nearby, too.
The only complaint I have was that the public address speaker in the hotel room had a tendency to "click" at odd times of the day, with enough volume to interrupt a midday nap.
Overall, I would stay here if I again had business in Chisinau.