There is tram right outside of the hotel which will take you to Prague's important districts. One tram stop from hotel, there is Andel station which is a convenient shopping center. They have mall, pharmacy, restaurants and Tesco supermarket.Hotel is convenient , clean and pretty safe.
The downside is the neighborhoold looks "old" and lack of maintanence,but safe. There is no safe lockbox in the hotel. I recommend carry the valuable with you. I stay over 4 days over there and I think people over there are generally nice, friendly and helpful. Just stay away from occasional hobo.